Trimethylglycine, commonly known as TMG or Betaine Anhydrous is a naturally occurring compound that plays a pivotal role in the methylation cycle, which is essential for the regulation of various bodily functions.
 
Some individuals have variations to the MTHFR gene, which can impact the methylation process. Studies suggest that up to 50% of the population may have variations in this gene, leading to difficulties in methylating efficiently. This means they may not even use b-vitamins effectively.